Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1b- induced accumulation of b-amyloid and cell death
نویسندگان
چکیده
1 Department of Neurology, University Medical Centre Göttingen, 37075 Göttingen, Germany 2 Department of Neuroimmunology, Institute for Multiple Sclerosis Research and Hertie Foundation, University Medical Centre Göttingen, 37073 Göttingen, Germany 3 The Brooke Laboratories, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK 4 Department of Trauma and Reconstructive Surgery, University Medical Centre Göttingen, 37075 Göttingen, Germany 5 Department of Neuropathology, University Medical Centre Göttingen, 37075 Göttingen, Germany 6 Neuroimmunology Unit, Department of Pathophysiology, National University of Athens Medical School, Athens 11527, Greece
منابع مشابه
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death.
Sporadic inclusion body myositis is a severely disabling myopathy. The design of effective treatment strategies is hampered by insufficient understanding of the complex disease pathology. Particularly, the nature of interrelationships between inflammatory and degenerative pathomechanisms in sporadic inclusion body myositis has remained elusive. In Alzheimer's dementia, accumulation of β-amyloid...
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BACKGROUND Mutations of the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE)-gene are causally related to GNE myopathy. Yet, underlying pathomechanisms of muscle fibre damage have remained elusive. In sporadic inclusion body myositis (sIBM), the pro-inflammatory cell-stress mediators αB-crystallin and inducible nitric oxide synthase (iNOS) are crucial markers of the disease ...
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Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
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